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Receptor crosstalk and combined signaling: Exploring whether simultaneous activation of two upstream pathways produces additive or synergistic signaling patterns in functional assays (model-dependent and protocol-specific)

However, many of its visible and internal signs are linked to a decline in cellular function and hormone production

This proposed hierarchical framework requires validation through systematic metabolomic and functional studies to establish the relative contributions of different metabolites, thereby informing targeted therapeutic strategies (Figure 1)

GHRH (Growth Hormone-Releasing Hormone) A hypothalamic peptide that signals the pituitary gland to produce and release growth hormone

10.1002/ptr.5104 73 DixitS.BernardoA.WalkerJ